Vasorin/ATIA Promotes Cigarette Smoke–Induced Transformation of Human Bronchial Epithelial Cells by Suppressing Autophagy-Mediated Apoptosis
Identifieur interne : 000283 ( Main/Exploration ); précédent : 000282; suivant : 000284Vasorin/ATIA Promotes Cigarette Smoke–Induced Transformation of Human Bronchial Epithelial Cells by Suppressing Autophagy-Mediated Apoptosis
Auteurs : Wenshu Chen [États-Unis] ; Qiong Wang [États-Unis] ; Xiuling Xu [États-Unis] ; Bryanna Saxton [États-Unis] ; Mathewos Tessema [États-Unis] ; Shuguang Leng [États-Unis] ; Swati Choksi [États-Unis] ; Steven A. Belinsky [États-Unis] ; Zheng-Gang Liu [États-Unis] ; Yong Lin [États-Unis]Source :
- Translational Oncology [ 1936-5233 ] ; 2019.
Abstract
Url:
DOI: 10.1016/j.tranon.2019.09.001
PubMed: 31760267
PubMed Central: 6883318
Affiliations:
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Belinsky</name><affiliation wicri:level="1"><nlm:aff id="aff1">Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. 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SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. 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SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108</wicri:regionArea><wicri:noRegion>87108</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Qiong" sort="Wang, Qiong" uniqKey="Wang Q" first="Qiong" last="Wang">Qiong Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108</wicri:regionArea><wicri:noRegion>87108</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Xiuling" sort="Xu, Xiuling" uniqKey="Xu X" first="Xiuling" last="Xu">Xiuling Xu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108</wicri:regionArea><wicri:noRegion>87108</wicri:noRegion></affiliation></author><author><name sortKey="Saxton, Bryanna" sort="Saxton, Bryanna" uniqKey="Saxton B" first="Bryanna" last="Saxton">Bryanna Saxton</name><affiliation wicri:level="1"><nlm:aff id="aff1">Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108</wicri:regionArea><wicri:noRegion>87108</wicri:noRegion></affiliation></author><author><name sortKey="Tessema, Mathewos" sort="Tessema, Mathewos" uniqKey="Tessema M" first="Mathewos" last="Tessema">Mathewos Tessema</name><affiliation wicri:level="1"><nlm:aff id="aff1">Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108</wicri:regionArea><wicri:noRegion>87108</wicri:noRegion></affiliation></author><author><name sortKey="Leng, Shuguang" sort="Leng, Shuguang" uniqKey="Leng S" first="Shuguang" last="Leng">Shuguang Leng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108</wicri:regionArea><wicri:noRegion>87108</wicri:noRegion></affiliation></author><author><name sortKey="Choksi, Swati" sort="Choksi, Swati" uniqKey="Choksi S" first="Swati" last="Choksi">Swati Choksi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Bethesda, MD, 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Bethesda, MD, 20892</wicri:regionArea><wicri:noRegion>20892</wicri:noRegion></affiliation></author><author><name sortKey="Belinsky, Steven A" sort="Belinsky, Steven A" uniqKey="Belinsky S" first="Steven A." last="Belinsky">Steven A. Belinsky</name><affiliation wicri:level="1"><nlm:aff id="aff1">Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108</wicri:regionArea><wicri:noRegion>87108</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Zheng Gang" sort="Liu, Zheng Gang" uniqKey="Liu Z" first="Zheng-Gang" last="Liu">Zheng-Gang Liu</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Bethesda, MD, 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Bethesda, MD, 20892</wicri:regionArea><wicri:noRegion>20892</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yong" sort="Lin, Yong" uniqKey="Lin Y" first="Yong" last="Lin">Yong Lin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108</wicri:regionArea><wicri:noRegion>87108</wicri:noRegion></affiliation></author></analytic><series><title level="j">Translational Oncology</title><idno type="eISSN">1936-5233</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>BACKGROUND:</italic> Escaping cell death pathways is an important event during carcinogenesis. We previously identified anti-TNFα-induced apoptosis (ATIA, also known as vasorin) as an antiapoptotic factor that suppresses reactive oxygen species (ROS) production. However, the role of vasorin in lung carcinogenesis has not been investigated. <italic>METHODS:</italic> Vasorin expression was examined in human lung cancer tissues with immunohistochemistry and database analysis. Genetic and pharmacological approaches were used to manipulate protein expression and autophagy activity in human bronchial epithelial cells (HBECs). ROS generation was measured with fluorescent indicator, apoptosis with release of lactate dehydrogenase, and cell transformation was assessed with colony formation in soft agar. <italic>RESULTS:</italic> Vasorin expression was increased in human lung cancer tissues and cell lines, which was inversely associated with lung cancer patient survival. Cigarette smoke extract (CSE) and benzo[a]pyrene diol epoxide (BPDE)–induced vasorin expression in HBECs. Vasorin knockdown in HBECs significantly suppressed CSE-induced transformation in association with enhanced ROS accumulation and autophagy. Scavenging ROS attenuated autophagy and cytotoxicity in vasorin knockdown cells, suggesting that vasorin potentiates transformation by impeding ROS-mediated CSE cytotoxicity and improving survival of the premalignant cells. Suppression of autophagy effectively inhibited CSE-induced apoptosis, suggesting that autophagy was pro-apoptotic in CSE-treated cells. Importantly, blocking autophagy strongly potentiated CSE-induced transformation. <italic>CONCLUSION:</italic> These results suggest that vasorin is a potential lung cancer–promoting factor that facilitates cigarette smoke–induced bronchial epithelial cell transformation by suppressing autophagy-mediated apoptosis, which could be exploited for lung cancer prevention.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, R L" uniqKey="Siegel R">R.L. Siegel</name></author><author><name sortKey="Miller, K D" uniqKey="Miller K">K.D. 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Belinsky</name><name sortKey="Choksi, Swati" sort="Choksi, Swati" uniqKey="Choksi S" first="Swati" last="Choksi">Swati Choksi</name><name sortKey="Leng, Shuguang" sort="Leng, Shuguang" uniqKey="Leng S" first="Shuguang" last="Leng">Shuguang Leng</name><name sortKey="Lin, Yong" sort="Lin, Yong" uniqKey="Lin Y" first="Yong" last="Lin">Yong Lin</name><name sortKey="Liu, Zheng Gang" sort="Liu, Zheng Gang" uniqKey="Liu Z" first="Zheng-Gang" last="Liu">Zheng-Gang Liu</name><name sortKey="Saxton, Bryanna" sort="Saxton, Bryanna" uniqKey="Saxton B" first="Bryanna" last="Saxton">Bryanna Saxton</name><name sortKey="Tessema, Mathewos" sort="Tessema, Mathewos" uniqKey="Tessema M" first="Mathewos" last="Tessema">Mathewos Tessema</name><name sortKey="Wang, Qiong" sort="Wang, Qiong" uniqKey="Wang Q" first="Qiong" last="Wang">Qiong Wang</name><name sortKey="Xu, Xiuling" sort="Xu, Xiuling" uniqKey="Xu X" first="Xiuling" last="Xu">Xiuling Xu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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